Abstract
We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Binding Sites
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Cell Cycle Proteins / antagonists & inhibitors*
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Chromogenic Compounds
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Fluorine
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Kinetics
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Models, Molecular
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Naphthoquinones / chemistry*
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Naphthoquinones / pharmacology*
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Protein Binding
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Thermodynamics
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cdc25 Phosphatases / antagonists & inhibitors*
Substances
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2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
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Antineoplastic Agents
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Cell Cycle Proteins
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Chromogenic Compounds
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Naphthoquinones
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Fluorine
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cdc25 Phosphatases